Express Scripts Express Scripts Takes Doctors Role Nationwide

My wife has taken a well known medicine for years successfully.  Her doctor ordered a refill of the same medicine recently.  Express Scripts filled it with a generic.  They never informed the doctor or the patient.  They claim they have the right to change a doctor's prescription without notifying doctor or patient and do not require anyone's approval.  The generic is of a family of medicines my wife has previously taken and had very adverse results.  Express Scripts refuses to take back the medine provided and will not refund the cost of providing the wrong order - $100.00!! Nor provide the originally prescribed medicine. The new generic has only been on the market a few weeks. When did a pharmarist gain the right to change a doctor's order without approval?  My wife goes to an experienced professional licsened doctor who has compiled a medical record on her case.  Express Scripts has never seen my wife nor examined her nor has access to her medical history.  How can they dispense an unkown medicine under these circumstances? By the way if Express Scripts agrees to dispense the prescribed medicine they will charge me an additional $160.00.  My advise to everyone is:  Have your doctor wirte the words "no substitutes" on every prescription, but I am unsure if this would prevent Express Scripts from playing doctor.